AP®︎ Biology: Unit 4 Flashcards

Master key terms and definitions for Unit 4 of AP Biology – Cell Communication and Cell Cycle to help you prep for quizzes and the AP exam.


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Term

Cell Communication

Definition

The process by which cells detect, send, and respond to information.

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Cell Communication
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The process by which cells detect, send, and respond to information.

4.1.A
Direct Cell-to-Cell Contact
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Communication that occurs when neighboring cells physically touch and exchange information.

4.1.A4.1.A.1
Chemical Signaling
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Communication in which cells release signaling molecules that bind to target cells.

4.1.A4.1.A.1
Local Signaling and Long-Distance Signaling
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Nearby targets respond to local regulators; distant targets respond to signals carried farther, often in blood.

4.1.B
Local Regulators
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Short-range signaling molecules that affect cells close to the releasing cell.

4.1.B4.1.B.1
Antigen-Presenting Cells (APCs)
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Immune cells that display antigen fragments on their surface to activate other immune cells.

4.1.A4.1.A.1
Helper T-Cells
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Immune cells that recognize presented antigens and coordinate other parts of the immune response.

4.1.A4.1.A.1
Killer T-Cells
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Immune cells that directly contact and destroy infected or abnormal body cells.

4.1.A4.1.A.1
Neurotransmitters
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Chemical messengers released by neurons that signal across short distances to nearby cells.

4.1.B4.1.B.1
Plant Immune Response
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Chemical signaling by plant cells that alerts nearby cells to pathogens or herbivore attack.

4.1.B4.1.B.1
Morphogens
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Local signaling molecules that form concentration gradients and guide embryonic development.

4.1.B4.1.B.1
Insulin
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A hormone that promotes glucose uptake by body cells and lowers blood sugar.

4.1.B4.1.B.2
Human Growth Hormone
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A hormone that stimulates growth, cell division, and protein synthesis in target tissues.

4.1.B4.1.B.2
Thyroid Hormones
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Hormones that regulate metabolic rate, growth, and development throughout the body.

4.1.B4.1.B.2
Testosterone and Estrogen
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Sex hormones that regulate reproductive development, function, and secondary sex characteristics.

4.1.B4.1.B.2
Receptor Protein
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A protein that binds a specific signal and initiates a cellular change.

4.2.B4.2.B.1
Ligand-Binding Domain
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The receptor region that specifically recognizes and binds a particular chemical messenger.

4.2.B4.2.B.1
Cell Surface, Cytoplasmic, And Nuclear Receptors
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Membrane receptors bind external signals; intracellular receptors bind signals inside the cell.

4.2.B4.2.B.1
Conformational Change
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A shape change in a receptor that starts intracellular signaling after ligand binding.

4.2.B4.2.B.2
G Protein-Coupled Receptors (GPCRs)
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Seven-pass membrane receptors that activate G proteins to relay external signals inward.

4.2.B4.2.B.1
Phosphorylation Cascade
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A sequence of protein activations caused by adding phosphate groups at each step.

4.2.A4.2.A.2
Signal Amplification
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One signaling event activates many molecules, producing a much larger cellular effect.

4.2.B4.2.B.2
Second Messengers
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Small intracellular molecules that relay and amplify signals from activated receptors.

4.2.B4.2.B.2
Cyclic AMP (cAMP)
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A common second messenger that activates intracellular proteins and amplifies signaling.

4.2.B4.2.B.2
Ligand-Gated Ion Channels
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Membrane channels that open or close when a signaling molecule binds.

4.2.B4.2.B.2
Signal Transduction Pathway
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A series of reception, transduction, and response steps linking a signal to cellular change.

4.2.A4.2.A.1
Hormones
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Chemical signaling molecules released by one cell type that travel long distances, often through the bloodstream, to target cells.

4.2.B4.2.B.2
Ligand
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A signaling molecule that binds specifically to a receptor protein and initiates a cellular response.

4.2.B4.2.B.1
Signal Transduction
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Conversion of an external signal into specific intracellular responses through a signaling pathway.

4.3.A
Epinephrine and Glycogen Breakdown
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A hormone signal that triggers liver cells to convert glycogen into glucose.

4.3.A4.3.A.1
Cytokines
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Signaling proteins that regulate gene expression, cell replication, and immune cell division.

4.3.B4.3.B.1
Yeast Mating Pheromones
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Chemical signals that bind receptors and activate genes required for yeast mating.

4.3.B4.3.B.1
Ethylene
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A plant hormone gas that triggers enzyme production and fruit ripening responses.

4.3.B4.3.B.1
HOX Genes
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Developmental regulatory genes that specify body regions and organize animal body plans.

4.3.B4.3.B.1
Mutation Effects on Signaling Pathways
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Changes in receptors or pathway proteins can weaken, block, or overactivate downstream responses.

4.3.B4.3.B.1
Receptor Protein Domains
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Specific structural regions whose alteration can change ligand binding or signal transmission.

4.3.B4.3.B.1
Chemical Activators and Inhibitors of Signaling
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Molecules that bind pathway components and either stimulate or block signal transduction.

4.3.B4.3.B.2
Signal Reception
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Detection of a signaling molecule when it binds to a specific receptor protein.

4.3.B
Quorum Sensing
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Bacterial or microbial communication using secreted signaling molecules to detect population density and coordinate gene expression and behavior.

4.3.A4.3.A.1
Cellular Responses to Signals
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Cell signaling can produce responses such as changes in gene expression, enzyme activity, metabolism, secretion, movement, cell growth, phenotype, or programmed cell death.

4.3.A4.3.A.1
Homeostasis
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Maintenance of a relatively stable internal environment despite internal or external changes.

4.4.A4.4.A.1
Feedback Mechanisms
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Regulatory loops in which a system's output influences its own activity.

4.4.A4.4.A.1
Negative Feedback
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A response that counteracts a change and returns conditions toward a set point.

4.4.A4.4.A.1
Positive Feedback
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A response that amplifies a change and moves conditions farther from a set point.

4.4.A4.4.A.1
Set Point
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The target value or normal range a regulated condition tends to return to.

4.4.A4.4.A.1
Blood Glucose Regulation by Insulin and Glucagon
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Insulin lowers blood sugar by promoting storage; glucagon raises it by stimulating glycogen breakdown.

4.4.A4.4.A.1
Labor and Childbirth Feedback Loop
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Cervical stretching triggers oxytocin release, which intensifies contractions until birth ends the loop.

4.4.A4.4.A.1
Oxytocin
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A hormone that stimulates uterine contractions and milk release during positive feedback responses.

4.4.A4.4.A.1
Lactation in Mammals
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Suckling stimulates hormone release, increasing milk production and release until nursing stops.

4.4.A4.4.A.1
Fruit Ripening
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Ethylene from ripening fruit stimulates nearby fruits to ripen and release more ethylene.

4.4.A4.4.A.1
Molecular, Cellular, and Organismal Levels of Feedback
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Regulation occurs through molecule interactions, cell responses, and coordinated whole-body system changes.

4.4.A4.4.A.1
Insulin and Glucagon
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Pancreatic hormones that lower or raise blood glucose to maintain homeostasis.

4.4.A4.4.A.1
Diabetes and Feedback Disruption
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A disorder in which insulin production or response fails, disrupting blood glucose homeostasis.

4.4.A4.4.A.1
Positive vs. Negative Feedback
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One amplifies change, while the other reverses change to restore a set point.

4.4.A4.4.A.1
Cell Cycle
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Highly regulated sequence of growth, DNA replication, and division in eukaryotic cells.

4.5.A4.5.A.1
Sister Chromatids and Centromere
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Identical DNA copies joined at a centromere after replication during S phase.

4.5.A4.5.A.1
Mitosis
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Nuclear division that produces two genetically identical daughter cells with complete genomes.

4.5.B4.5.B.1
Functions of Mitosis
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Enables growth, tissue repair, and asexual reproduction in eukaryotic organisms.

4.5.B4.5.B.1
Mitotic Spindle
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Microtubule structure that attaches to chromosomes and moves them during mitosis.

4.5.B4.5.B.1
Kinetochores
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Protein structures on centromeres where spindle fibers attach to move chromatids.

4.5.B
Cytokinesis
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Division of the cytoplasm that produces two separate daughter cells after mitosis.

4.5.B4.5.B.1
Centrosomes
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Microtubule-organizing structures that replicate before mitosis and move to opposite poles.

4.5.A4.5.A.1
Chromatin
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Uncondensed DNA-protein complex present during interphase and replicated in S phase.

4.5.A4.5.A.1
Interphase
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G1, S, and G2 make up the stage when cells grow, replicate DNA, and prepare for division.

4.5.A4.5.A.1
Stages of Mitosis
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Prophase condenses chromosomes, metaphase aligns them, anaphase separates chromatids, and telophase reforms nuclei.

4.5.B4.5.B.1
Cytokinesis in Animal and Plant Cells
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Animal cells form a cleavage furrow, while plant cells build a cell plate.

4.5.B4.5.B.1
Cell Cycle Checkpoints
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Internal control points that stop or allow progression only when key conditions are met.

4.6.A4.6.A.1
G1, G2, and M Checkpoints
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G1 checks size, nutrients, signals, and DNA; G2 checks replication and damage; M checks spindle attachment.

4.6.A4.6.A.1
Cyclins and Cyclin-Dependent Kinases (CDKs)
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Regulatory proteins where cyclins activate CDKs to drive cell cycle transitions.

4.6.A4.6.A.2
Cyclin and CDK Activity Pattern
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Cyclin levels fluctuate, while CDK levels stay relatively constant and work only when activated.

4.6.A4.6.A.2
Cancer
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Uncontrolled cell division caused by failed regulation and checkpoint bypass.

4.6.B4.6.B.1
Apoptosis
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Programmed cell death that eliminates cells that are damaged, unnecessary, or beyond repair, often in response to specific signals.

4.6.B4.6.B.1
G0 Phase
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A resting, nondividing state entered when cells exit the cell cycle or pause, often after G1, until receiving appropriate signals.

4.6.A4.6.A.1