AP®︎ Biology: Topic 4.2 Flashcards

Master key terms and definitions for Topic 4.2 of AP Biology – Introduction to Signal Transduction to help you prep for quizzes and the AP exam.


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Term

Ligand

Definition

A signaling molecule that binds specifically to a receptor protein on or in a target cell.

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Ligand
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A signaling molecule that binds specifically to a receptor protein on or in a target cell.

4.2.B4.2.B.1
Receptor Protein
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A protein that binds a specific signal and initiates a cellular change.

4.2.B4.2.B.1
Ligand-Binding Domain
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The receptor region that specifically recognizes and binds a particular chemical messenger.

4.2.B4.2.B.1
Cell Surface, Cytoplasmic, And Nuclear Receptors
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Membrane receptors bind external signals; intracellular receptors bind signals inside the cell.

4.2.B4.2.B.1
Conformational Change
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A shape change in a receptor that starts intracellular signaling after ligand binding.

4.2.B4.2.B.2
G Protein-Coupled Receptors (GPCRs)
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Seven-pass membrane receptors that activate G proteins to relay external signals inward.

4.2.B4.2.B.1
Phosphorylation Cascade
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A sequence of protein activations caused by adding phosphate groups at each step.

4.2.A4.2.A.2
Signal Amplification
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One signaling event activates many molecules, producing a much larger cellular effect.

4.2.B4.2.B.2
Second Messengers
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Small intracellular molecules that relay and amplify signals from activated receptors.

4.2.B4.2.B.2
Cyclic AMP (cAMP)
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A common second messenger that activates intracellular proteins and amplifies signaling.

4.2.B4.2.B.2
Cellular Responses To Signaling
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Outcomes include cell growth, molecule secretion, gene expression, or altered enzyme activity.

4.2.B4.2.B.2
Hormones
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Chemical messengers that travel long distances through the bloodstream to target cells.

4.2.B4.2.B.2
Ligand-Gated Ion Channels
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Membrane channels that open or close when a signaling molecule binds.

4.2.B4.2.B.2
Signal Transduction Pathway
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A series of reception, transduction, and response steps linking a signal to cellular change.

4.2.A4.2.A.1